Shifts in attentional demand are accompanied by sex-specific patterns of insula-frontal cortical interactions in mice

We measured local field potentials (LFPs) in the mouse insula and frontal cortex during a translationally-relevant touchscreen-based task of attentionManipulation of stimulus frequency during the task increased the demand on vigilance and response inhibitionIn male mice, frontal cortex-driven synchrony in slow frequency bands reflected task rules, while theta-gamma coupling reflected errors when demand on response inhibition was increasedIn female mice, bidirectionally-driven synchrony in slow frequency bands also reflected task rules, while theta-gamma coupling reflected errors when demand on vigilance was increased.