Flash Communication: Intermolecular C(sp <sup>2</sup> )–H Activation in a Palladium(II) Complex Supported by a <i>p</i> -Me <sub>2</sub> N-Thiapyridinophane Ligand
We report the synthesis and characterization of a new p-dimethylamino-substituted thiapyridinophane ligand (pNMe2NCHS2) and its palladium complexes. The electron-rich dimethylamino groups engender the palladium compounds with several unusual properties compared to the parent unsubstituted NCHS2 ligand. A facile room-temperature C(sp2)–H activation of the pNMe2NCHS2 ligand was observed, which is facilitated by the p-dimethylamino group acting as an internal base. NMR spectroscopic and mechanistic studies were conducted to gain insight into the possible mechanism of the C–H activation process.
Authors
- Liviu M. Mirica (ORCID: https://orcid.org/0000-0003-0584-9508)
- Sagnik Chakrabarti (ORCID: https://orcid.org/0000-0002-0757-1127)
- Jonathan G. Leung (ORCID: https://orcid.org/0000-0003-3836-9375)
- Nicholas D. Cedron
Institutions
- University of Illinois Urbana-Champaign (US)
Publication Details
- Journal
- Organometallics
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1021/acs.organomet.5c00336
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00