External validation of a microRNA thyroid classifier: a real-world prospective study
The mir-THYpe full molecular test supported 95.5% of clinical decisions when negative and 89.8% when positive, reducing surgery rates by 79.5%. Therefore, the integration of this microRNA-based classifier into clinical practice represents a valuable tool in managing indeterminate thyroid nodules, reducing unnecessary thyroidectomies, and conserving valuable healthcare resources.
Authors
- Daniel Knabben Ortellado
- Maria Isabel Cunha Vieira Cordioli (ORCID: https://orcid.org/0000-0001-5179-6916)
- André Wüst Zibetti (ORCID: https://orcid.org/0000-0002-9545-0324)
- Jalmir Rogério Aust
- Eduarda Gregorio Arnaut Lima
- Acklei Viana
- Gustavo Philippi de Los Santos
- Alvin Laemmel
- K. Marcello
Institutions
- Universidade Federal de Santa Catarina (BR)
- Polydoro Ernani de São Thiago University Hospital (BR)
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (BR)
- Centro de Pesquisas Oncológicas (BR)
Publication Details
- Journal
- European Thyroid Journal
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1530/etj-25-0105
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00