Prognostic value of serum free light chain abnormalities in diffuse large B-cell lymphoma
Abnormal serum FLC levels were associated with adverse clinical features and inferior survival outcomes in DLBCL, particularly monoclonal FLC in the non-GCB subtype. These findings support the utility of serum FLC assessment as a simple, accessible biomarker for risk stratification in DLBCL, though it was not confirmed as an independent risk factor in multivariate analysis.
Authors
- Zhuxia Jia
- Wei Xu (ORCID: https://orcid.org/0000-0001-5404-7523)
- Jie Liu (ORCID: https://orcid.org/0000-0003-0926-5470)
- Jin Li (ORCID: https://orcid.org/0000-0002-1268-8864)
- Wei Han (ORCID: https://orcid.org/0000-0002-0685-9583)
- Xuzhang Lu
Institutions
- Changzhou No.2 People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Changzhou Third People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fonc.2025.1694343
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Medical University