Succinate–GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NAD+ production to alleviate HFpEF
These findings identify the succinate-GPR91 axis as a critical regulator of cardiometabolic homeostasis and a potential therapeutic target in HFpEF.
Authors
- Wenhui Niu
- Jie Du (ORCID: https://orcid.org/0000-0002-8038-7852)
- Yumeng Jia (ORCID: https://orcid.org/0000-0003-0060-9257)
- Qun Zhang (ORCID: https://orcid.org/0000-0003-2208-7998)
- Lu Liu (ORCID: https://orcid.org/0000-0001-5101-5067)
- Lei Wang (ORCID: https://orcid.org/0000-0003-0184-307X)
- Dingwei Li
- Tantan Dai (ORCID: https://orcid.org/0000-0002-9607-5124)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1186/s12933-025-03030-x
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00