Sex-dependent alterations of salivary microbiome in Parkinson’s disease: associations with motor and non-motor clinical phenotypes
The salivary microbiome in Parkinson's disease exhibits sex specific alterations that track clinical burden, supporting sex aware development of salivary biomarkers and microbiota focused strategies. Validation in larger longitudinal cohorts with multi omics and standardized oral and medication metadata is warranted.
Authors
- Ruyi Chen (ORCID: https://orcid.org/0000-0002-3068-7988)
- Li Du (ORCID: https://orcid.org/0000-0001-8864-6380)
- Lishun Xiao (ORCID: https://orcid.org/0000-0002-0879-252X)
- Jie Zu
- Liguo Dong
- Jienan Zhu
- Min Xu (ORCID: https://orcid.org/0000-0003-1558-4283)
- Chuanying Xu (ORCID: https://orcid.org/0009-0006-0851-9298)
- Yuting Zhang (ORCID: https://orcid.org/0000-0002-2381-4002)
- Chunfeng Liu (ORCID: https://orcid.org/0000-0001-5360-616X)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-9489-5965)
- Siyan Chen (ORCID: https://orcid.org/0000-0003-1257-8988)
- Hui Zhao (ORCID: https://orcid.org/0000-0003-1327-2577)
Institutions
- Xuzhou Medical College (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fmolb.2025.1726620
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Government of Jiangsu Province
- Xuzhou Medical University