DNA methylation age acceleration mediates the relationship between systemic inflammation and cognitive impairment
Systemic inflammation is associated with cognitive impairment, with suggestive evidence that this relationship is partially mediated through DNA methylation age acceleration.
Authors
- Matthew Zawistowski (ORCID: https://orcid.org/0000-0002-3005-083X)
- César Higgins Tejera (ORCID: https://orcid.org/0000-0001-5999-3607)
- Dominika Šeblová (ORCID: https://orcid.org/0000-0001-6147-6895)
- Lindsay C. Kobayashi (ORCID: https://orcid.org/0000-0003-2725-3107)
- Peiyao Zhu (ORCID: https://orcid.org/0009-0004-5266-5570)
- Erin B. Ware (ORCID: https://orcid.org/0000-0003-4731-8158)
- Kelly M. Bakulski (ORCID: https://orcid.org/0000-0002-9605-6337)
- Jennifer J. Manly (ORCID: https://orcid.org/0000-0002-9481-7497)
- Bhramar Mukherjee (ORCID: https://orcid.org/0000-0003-0118-4561)
- Margaret T. Hicken (ORCID: https://orcid.org/0000-0001-6443-2249)
Institutions
- Charles University (CZ)
- University of Michigan (US)
- Columbia University (US)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1080/17501911.2025.2595905
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00