Effects of bolus injection rate on the pharmacodynamics and pharmacokinetics of propofol, etomidate and sufentanil in rats
These findings demonstrate that injection rate directly influences both therapeutic and adverse effects through alterations in pharmacokinetic parameters, particularly C<sub>max</sub>. Setting a reasonable injection rate in animal experiments will show positive significance and help reduce related safety risks, especially in the application of anesthetics. In addition, strategically optimizing the injection rate during the development of innovative drugs is expected to improve the predictive validity of translational research.
Authors
- Feng Qiu (ORCID: https://orcid.org/0000-0002-0450-229X)
- Sicheng Liu (ORCID: https://orcid.org/0000-0001-7332-8267)
- Deying Gong (ORCID: https://orcid.org/0000-0003-1637-0914)
- Wensheng Zhang (ORCID: https://orcid.org/0000-0002-2737-8623)
- Xiaoxiao Li (ORCID: https://orcid.org/0000-0002-1385-5898)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fvets.2025.1696260
- Primary Topic
- Veterinary Pharmacology and Anesthesia
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Natural Science Foundation of Sichuan Province
- Young Scientists Fund