Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma
We established a detailed screening protocol for drug repurposing to treat GBM. This approach targets a critical vulnerability of GBM cells by disrupting their bioenergetic balance. Since metabolic reprogramming and the associated Warburg effect are hallmarks of many cancers, not just GBM, we believe this approach holds significant potential for use against a wider range of tumors.
Authors
- Isabella Romeo (ORCID: https://orcid.org/0000-0002-5799-7863)
- Stefano Alcaro (ORCID: https://orcid.org/0000-0002-0437-358X)
- Alfredo Budillon (ORCID: https://orcid.org/0000-0002-6330-6053)
- Maria Serena Roca (ORCID: https://orcid.org/0000-0002-9621-0939)
- Andrea Polo (ORCID: https://orcid.org/0000-0002-1540-2761)
- Marco G. Paggi (ORCID: https://orcid.org/0000-0002-9445-442X)
- Palmina Bagnara (ORCID: https://orcid.org/0000-0003-1563-7381)
- Elena Di Gennaro (ORCID: https://orcid.org/0000-0001-6223-7845)
- Gianmarco Gualtieri (ORCID: https://orcid.org/0000-0003-2086-8272)
- Francesco Ortuso (ORCID: https://orcid.org/0000-0001-6235-8161)
- Gennaro Ciliberto (ORCID: https://orcid.org/0000-0003-2851-8605)
- Claudia Abbruzzese (ORCID: https://orcid.org/0000-0003-3301-9421)
- Giulia Fanelli
- Susan Costantini (ORCID: https://orcid.org/0000-0002-1076-2362)
Institutions
- Magna Graecia University (IT)
- Ministry of Defence (IT)
- National Cancer Institute (MY)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Cellular Therapeutics (United Kingdom) (GB)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12967-025-07444-9
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Ministero della Salute
- Istituto Superiore di Sanità