The Discovery of Antibacterial Cembranoids from the Soft Coral Lobophytum crassum by DeepSAT Analysis

Eight previously unreported cembranoids (<b>1</b>-<b>8</b>), along with four known ones (<b>9</b>-<b>12</b>), have been isolated and identified from the soft coral <i>Lobophytum crissum</i> collected from the South China Sea under the guidance of HSQC-based DeepSAT analysis for targeted isolation. The structures of the new compounds were determined by comprehensive spectroscopic analysis, QM-NMR, TDDFT-ECD calculations, and comparison with reported literature data from analogs. In in vitro bioassays, all the isolated compounds have been screened for their antibacterial and antiproliferative activities.