Mutant IL-2-expressing mesenchymal stromal cells promote regulatory T cells proliferation and activation in collagen induced arthritis mice
Mutant IL-2 enhances Treg function and proliferation while exerting reduced effects on CD8<sup>+</sup> T and NK cell activation. MSC expressing mutant IL-2 demonstrates therapeutic benefits in CIA by increasing the proportion of Treg cells and reducing the proportion of CD8<sup>+</sup> T cells.
Authors
- Fan Yang (ORCID: https://orcid.org/0000-0002-4323-2560)
- Haolin Wu (ORCID: https://orcid.org/0000-0001-5006-3585)
- Zhicheng Tang (ORCID: https://orcid.org/0009-0003-1890-7209)
- Xiaojun Tang (ORCID: https://orcid.org/0000-0002-2442-1446)
- Yue Wang (ORCID: https://orcid.org/0009-0002-8013-780X)
- Huayong Zhang
- Jingyi Shen (ORCID: https://orcid.org/0009-0009-6223-069X)
- Huiming Hong
- Fanzhang Yin
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s13075-025-03623-7
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00