L-Fucose alleviates inflammation, pyroptosis and mitochondrial injury in obesity-related cardiac injury via TLR4/MyD88/NF-κB pathway
These findings demonstrated that Fuc mitigated cardiac inflammation, pyroptosis and mitochondrial injury by inhibiting the TLR4/MyD88/NF-κB pathway, highlighting its potential as a therapeutic agent for obesity-associated cardiac injury.
Authors
- Wei Feng (ORCID: https://orcid.org/0000-0002-8096-2212)
- Jiaxin Gong (ORCID: https://orcid.org/0009-0006-2650-8314)
- Zhaoqiang Cui (ORCID: https://orcid.org/0000-0001-5978-4434)
- Tianyu Wu (ORCID: https://orcid.org/0000-0002-4295-7172)
- Yongqiao Zhang (ORCID: https://orcid.org/0009-0007-6886-9254)
- Junbo Ge (ORCID: https://orcid.org/0000-0002-9360-7332)
- Ningzhi Zhang (ORCID: https://orcid.org/0000-0002-9570-4726)
Institutions
- Fudan University (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12967-025-06834-3
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China