Intratumoral Collinsella aerofaciens exhibits antitumor activity in endometrial carcinoma through activation of the p53 signaling pathway
This study identifies C. aerofaciens as a novel tumor-suppressive bacterium in EC, with mechanistic evidence linking its activity to p53 pathway activation. Gut microbiota modulates intratumoral microbial composition, suggesting potential dual-target therapeutic strategies for EC.
Authors
- Sidi Li (ORCID: https://orcid.org/0009-0005-4054-7726)
- Zhiqing Liang (ORCID: https://orcid.org/0009-0002-2994-3689)
- Kaijian Ling
- Yanzhou Wang (ORCID: https://orcid.org/0000-0002-5985-5244)
- Yiwen Tan
- Xin Zhou (ORCID: https://orcid.org/0000-0002-9324-4308)
- Yingfan Chen
- Wenting Wang (ORCID: https://orcid.org/0000-0002-8344-0102)
- Tingting Wu (ORCID: https://orcid.org/0000-0002-0812-2059)
- Sisi Li (ORCID: https://orcid.org/0000-0002-7290-8128)
- Lingjun Huang
- Cai-Rong Zhang (ORCID: https://orcid.org/0000-0003-1333-5785)
- Lingyi Wang (ORCID: https://orcid.org/0000-0002-9473-7163)
- Muheng Tao
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Dalian Medical University (CN)
- Beijing Institute of Big Data Research (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Chongqing Emergency Medical Center (CN)
- Children's Hospital of Chongqing Medical University (CN)
- First People's Hospital of Chongqing (CN)
- Hainan Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12967-025-07543-7
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00