Bromide‐Catalyzed Site‐Selective C–H Selenylation of Pyridones With Se Powder and Boronic Acids
Abstract Herein, a metal‐free and general platform for the direct (di‐ or mono‐)selenylation at the C3 and C5 position of pyridones via bromide catalysis, using Se powder and boronic acids as the selenyl precursors, was successfully disclosed. This strategy proceeded with high site‐selectivity under the directing group‐free and transition‐metal‐free conditions. Simple catalytic system, high efficiency, operational simplicity, excellent functional group tolerance, strong chemical‐oxidant free, and easily scale‐up, were shown in this method. Furthermore, the mechanistic experiments indicated that a radical pathway was possibly involved.
Authors
- Ying Xia (ORCID: https://orcid.org/0000-0002-4803-8599)
- Feng Zhao (ORCID: https://orcid.org/0000-0001-5810-744X)
- Jinhui Cai (ORCID: https://orcid.org/0000-0002-7624-5499)
- Zi Yang (ORCID: https://orcid.org/0000-0002-8377-118X)
- Mingming Yu (ORCID: https://orcid.org/0000-0002-4081-7774)
- Wenting Zhang (ORCID: https://orcid.org/0000-0003-2236-7148)
- Zijing Xing (ORCID: https://orcid.org/0009-0003-3411-1737)
- Huimei Zhong
Institutions
- Zhejiang Sci-Tech University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Changsha Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1002/ajoc.70273
- Citations
- 1
- Primary Topic
- Organoselenium and organotellurium chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.31