Age-Related Multigene Analysis of Colorectal Cancer Using Next-Generation Sequencing
Multigene panel sequencing revealed distinct age-related molecular patterns in CRC. Younger patients were more likely to harbor <i>NRAS</i> variants, whereas <i>KRAS</i> alterations predominated in older individuals. These findings underscore the relevance of NGS-based multigene profiling for risk stratification and personalized therapy in colorectal cancer.
Authors
- Monika Wawszczak-Kasza (ORCID: https://orcid.org/0000-0002-9153-2250)
- Jacek Bicki (ORCID: https://orcid.org/0000-0003-3031-0985)
- Piotr Lewitowicz (ORCID: https://orcid.org/0000-0002-5443-7975)
- Łukasz Nawacki (ORCID: https://orcid.org/0000-0001-9653-9841)
- Monika Kozłowska-Geller (ORCID: https://orcid.org/0000-0002-7061-2227)
- Wojciech Lewitowicz
Institutions
- Kielce University of Technology (PL)
- Jan Kochanowski University (PL)
Publication Details
- Journal
- Cancers
- Published
- 2025-12-06
- DOI
- https://doi.org/10.3390/cancers17243909
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00