Personalizing Clozapine in Treatment-Resistant Schizophrenia: The Role of MicroRNA Biomarkers—A Pilot Study
Because miRNAs regulate the expression of a wide range of genes, including those involved in clozapine's efficacy and safety, these findings underscore the need for further studies integrating pharmacoepigenetic and pharmacogenetic biomarkers. Our preliminary findings suggest that specific miRNAs could be candidate biomarkers associated with clozapine response in TRS, although these results require validation in larger and controlled studies.
Authors
- Karin Badavievich Mirzaev (ORCID: https://orcid.org/0000-0002-9307-4994)
- Sergey Mosolov (ORCID: https://orcid.org/0000-0002-5749-3964)
- R. A. Illarionov (ORCID: https://orcid.org/0000-0003-2711-748X)
- Aiperi K. Khasanova (ORCID: https://orcid.org/0000-0001-5391-0786)
- Д. Н. Сосин (ORCID: https://orcid.org/0000-0002-2314-7174)
- Аndrey S. Glotov (ORCID: https://orcid.org/0000-0002-7465-4504)
- Dmitry Alekseevich Sychev (ORCID: https://orcid.org/0000-0002-4496-3680)
- Anastasiia K. Popova (ORCID: https://orcid.org/0009-0008-3512-2557)
Institutions
- St Petersburg University (RU)
- Research Institute of Obstetrics and Gynecology named after D.O. Ott (RU)
- Russian Medical Academy of Continuous Professional Education (RU)
- Moscow Regional Psychiatry Hospital No.5 (RU)
- Federal Medical Research Centre for Psychiatry and Narcology (RU)
- Russian Scientific Center of Surgery (RU)
Publication Details
- Journal
- Current Issues in Molecular Biology
- Published
- 2025-12-07
- DOI
- https://doi.org/10.3390/cimb47121020
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Higher Education of the Russian Federation