Comprehensive Molecular Screening by Next Generation Sequencing of Gastrointestinal Stromal Tumors ( <scp>GISTs</scp> ): In Silico Analysis and Classification of Rare <scp> <i>KIT</i> </scp> Exon 11 Mutations
Our findings highlight the clinical relevance of integrating NGS into routine GIST management, particularly for the identification and interpretation of rare genetic variants. The study underscores the importance of data sharing and collective variant annotation to support accurate molecular classification, prognostic assessment, and therapeutic decision-making for individual patients.
Authors
- Paola Parrella (ORCID: https://orcid.org/0000-0001-6031-9636)
- Antonio Petracca (ORCID: https://orcid.org/0009-0004-3065-2285)
- Barbara Pasculli (ORCID: https://orcid.org/0000-0002-3333-0255)
- Michelina Rendina (ORCID: https://orcid.org/0000-0002-3818-5704)
- Bartolomeo Augello (ORCID: https://orcid.org/0000-0001-7475-6976)
- Paola Parente (ORCID: https://orcid.org/0000-0003-0591-6723)
- Michelina Coco
- Teresa Balsamo
- Paolo Graziano (ORCID: https://orcid.org/0000-0001-7066-7896)
- Evaristo Maiello (ORCID: https://orcid.org/0000-0003-3890-3435)
- Maria Grazia Rodriquenz (ORCID: https://orcid.org/0000-0002-3163-7982)
- Tommaso Mazza (ORCID: https://orcid.org/0000-0003-0434-8533)
- André R. Troiano
- Francesco Petrizzelli (ORCID: https://orcid.org/0000-0002-9478-7929)
- Magda Zanelli (ORCID: https://orcid.org/0000-0002-8733-9933)
Institutions
- Casa Sollievo della Sofferenza (IT)
- Agostino Gemelli University Polyclinic (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cam4.71430
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00