Verbascoside targets endothelial HIF-1α/ Lysyl oxidase signaling to attenuate glomerular injury in diabetic nephropathy
Endothelial HIF-1α/LOX signaling drives mesangial oxidative stress and fibrosis in DN. Verbascoside, a dual LOX/LOXL2 inhibitor, represents a promising therapeutic agent targeting this pathogenic axis.
Authors
- Ting‐Guo Kang (ORCID: https://orcid.org/0000-0003-3754-2420)
- Shuxin Li (ORCID: https://orcid.org/0009-0003-1477-4162)
- Zhaopeng Xu (ORCID: https://orcid.org/0000-0001-7279-2391)
- Huan Liu (ORCID: https://orcid.org/0000-0002-0253-647X)
- Bin Hou (ORCID: https://orcid.org/0000-0002-1858-2294)
- Kaixin Li (ORCID: https://orcid.org/0000-0003-4496-5448)
- Mengnan Li (ORCID: https://orcid.org/0000-0001-7461-3254)
- Zetong Wu
- Min Shi
- Yanan Li (ORCID: https://orcid.org/0000-0001-5999-0430)
Institutions
- Hebei Medical University (CN)
- Hebei University of Economics and Business (CN)
- Shijiazhuang University (CN)
- Hebei Yiling Hospital (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Redox Report
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1080/13510002.2025.2598110
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 0.00