Predictors of virological outcomes after analytical interruption of antiretroviral therapy and HTI vaccination in early treated people with HIV-1._
These findings confirm that HTI-specific T-cell magnitude at ATI initiation is the strongest predictor of ATI outcomes observed in AELIX002/003 studies and that a threshold of vaccine-induced HTI-specific T-cell responses can be used as futility criteria before ATI and/or guide participant selection in future HTI-based HIV cure trials aimed at achieving therapy-free remission.
Authors
- José Moltó (ORCID: https://orcid.org/0000-0003-4564-1963)
- Adrián Curran (ORCID: https://orcid.org/0000-0002-1263-0814)
- Ian McGowan (ORCID: https://orcid.org/0000-0002-6470-8476)
- Lucía Bailón (ORCID: https://orcid.org/0000-0001-7277-9314)
- Samandhy Cedeño (ORCID: https://orcid.org/0000-0001-8312-0208)
- José Ramón Arribas (ORCID: https://orcid.org/0000-0002-7410-9450)
- Devi SenGupta (ORCID: https://orcid.org/0000-0003-3811-8111)
- Beatriz Mothe (ORCID: https://orcid.org/0000-0001-9975-407X)
- Jeffrey J. Wallin (ORCID: https://orcid.org/0000-0002-5952-3813)
- Yovaninna Alarcón‐Soto (ORCID: https://orcid.org/0000-0002-9977-8634)
- Elena Vendrame (ORCID: https://orcid.org/0000-0002-5595-1773)
- Anuska Llano (ORCID: https://orcid.org/0000-0002-0133-9888)
- Romas Geleziunas (ORCID: https://orcid.org/0000-0002-9290-8811)
- Christian Brander (ORCID: https://orcid.org/0000-0002-0548-5778)
- Roger Paredes (ORCID: https://orcid.org/0000-0002-6553-691X)
- Marie-Pierre Malice
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Universitat Autònoma de Barcelona (ES)
- University of Pittsburgh (US)
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Statistics Belgium (BE)
- IrsiCaixa (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Hospital La Paz Institute for Health Research (ES)
- Centro de Investigación Biomédica en Red (ES)
- Institute of Research and Innovation Parc Tauli (ES)
- Gilead Sciences (United States) (US)
- Hospital Universitari Germans Trias i Pujol (ES)
- Fundació Lluita contra les Infeccions (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Case Western Reserve University (US)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1038/s43856-025-01266-y
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- Gilead Sciences
- European Commission
- National Institutes of Health
- Instituto de Salud Carlos III