Chronic cervical instability in mice and rats: a reproducible model to simulate human intervertebral disc degeneration
This innovative cervical instability model not only minimizes the risk of nerve injury and reduces animal stress compared to previous models but also offers a reproducible and ethically sound platform for investigating IVDD pathogenesis and testing potential therapeutic interventions.
Authors
- Kun Zhao (ORCID: https://orcid.org/0000-0002-6524-8715)
- Bing Zhou (ORCID: https://orcid.org/0000-0002-7568-8175)
- Z Chen
- Weiqi Lu (ORCID: https://orcid.org/0000-0002-9533-805X)
- Jun-Hao Tan (ORCID: https://orcid.org/0000-0003-1939-7557)
- Fuzhou Xu
- G. Zeng
- Kuan‐Yi Tu (ORCID: https://orcid.org/0000-0003-1869-4701)
- Dongyang Liao (ORCID: https://orcid.org/0009-0005-6931-2832)
- Xiangheng Dai
Institutions
- Guangdong Medical College (CN)
- Shaoguan University (CN)
- Shantou University (CN)
- Nanfang Hospital (CN)
- Yue Bei People's Hospital (CN)
- Shaoguan Railway Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-12-08
- DOI
- https://doi.org/10.7717/peerj.20465
- Primary Topic
- Cervical and Thoracic Myelopathy
- Type
- article
- Field-Weighted Citation Impact
- 0.00