Hypoxic migrasomes drive colorectal cancer liver metastasis by mediating CD5L+ macrophage efferocytosis via NRP2/PROX1 axis
These findings demonstrate that hypoxic CRC-derived migrasomes facilitate liver metastasis by reprogramming stromal and immune compartments, particularly through NRP2/PROX1-mediated education of macrophages toward a pro-efferocytic CD5L⁺ phenotype. Our study reveals a previously unrecognized intercellular communication axis involving migrasomes in CRC progression and provides a potential therapeutic target for metastatic disease.
Authors
- Yaoxing Huang (ORCID: https://orcid.org/0000-0001-6270-1644)
- Yi‐Wen Huang (ORCID: https://orcid.org/0000-0001-9220-8770)
- Longzhen Chen
- Y. Luo (ORCID: https://orcid.org/0009-0000-2535-1366)
Institutions
- Longgang Central Hospital (CN)
- Guangzhou First People's Hospital (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12967-025-07485-0
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59