The G9a-TRIM21 axis exacerbates diabetic renal ischemia-reperfusion injury by inducing methylation-dependent ubiquitination and degradation of FoxO3a to promote oxidative stress and pyroptosis
Our study reveals a novel G9a-TRIM21-FoxO3a regulatory axis in diabetic RIRI, where G9a-mediated methylation licenses FoxO3a ubiquitination and degradation, thereby promoting pyroptosis and oxidative stress. These findings identify G9a as a potential therapeutic target for preventing or treating diabetic kidney ischemia-reperfusion injury.
Authors
- Shiyu Huang (ORCID: https://orcid.org/0000-0002-7513-8800)
- Qingyuan Zheng (ORCID: https://orcid.org/0000-0003-4682-3857)
- Zhiyuan Chen (ORCID: https://orcid.org/0000-0002-6820-3678)
- Xinmiao Ni
- Jin Liu (ORCID: https://orcid.org/0000-0002-5707-2078)
- Xuke Qin (ORCID: https://orcid.org/0000-0001-9273-3081)
- Yufeng Xiong (ORCID: https://orcid.org/0000-0001-9810-1691)
- Jun Jian (ORCID: https://orcid.org/0000-0002-1406-4668)
- Hailiang Mei (ORCID: https://orcid.org/0000-0003-1781-5508)
- Shanshan Wan (ORCID: https://orcid.org/0000-0002-2243-0584)
- Zhiwei Yan (ORCID: https://orcid.org/0000-0002-2817-7516)
- Lei Wang (ORCID: https://orcid.org/0000-0001-8412-1130)
- Hao Liu (ORCID: https://orcid.org/0000-0003-1938-8925)
- Qiumin Lu (ORCID: https://orcid.org/0000-0001-9986-9950)
- Jingsong Wang (ORCID: https://orcid.org/0000-0001-5002-2636)
- Xiuheng Liu (ORCID: https://orcid.org/0000-0002-2633-9577)
- Xiaojie Zhao (ORCID: https://orcid.org/0000-0002-8080-0280)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1016/j.redox.2025.103964
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00