Regioselective Markovnikov Hydroalkylation of Unactivated Alkenes Enabled by Photoredox/Nickel Dual Catalysis
Developing practical strategies and a new reaction mode to access the versatile photocatalytic hydroalkylation of olefins with well-controlled regioselectivity remains highly desirable. Herein, we report a photoredox/nickel dual-catalyzed, regioselective hydroalkylation of unactivated alkenes by using toluene derivatives as alkyl sources, offering an efficient route for the selective construction of C(sp<sup>3</sup>)-C(sp<sup>3</sup>) bonds. This protocol features synthetic simplicity, avoidance of an external hydrogen source, and high regioselectivity, thereby expanding its potential utility in organic synthesis.
Authors
- Lei Shi (ORCID: https://orcid.org/0000-0002-2644-1168)
- Yu Zheng (ORCID: https://orcid.org/0000-0002-0411-3868)
- Xian‐Chen He
- Hua Yang (ORCID: https://orcid.org/0000-0002-5518-5255)
- Kai Chen (ORCID: https://orcid.org/0000-0003-1012-0383)
- Jie Gao (ORCID: https://orcid.org/0000-0002-1945-3048)
Institutions
- Central South University (CN)
- Shanghai Zhangjiang Laboratory (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1021/acs.orglett.5c04202
- Citations
- 1
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94