Nuclear translocation of Cx43 promotes to CRC progression and associates with β-catenin accumulation
We systematically identified nuclear Cx43 as a factor promoting CRC progression. These findings highlight the novel mechanism involving the nuclear translocation of Cx43 as a promoting factor in CRC progression, and enhance our understanding of the interplay between the TME and CRC progression.
Authors
- Wan‐Xi Yang (ORCID: https://orcid.org/0000-0001-9304-195X)
- Jian Wu (ORCID: https://orcid.org/0000-0001-7065-9917)
- Huan Wen
- Shuo Wang (ORCID: https://orcid.org/0000-0002-9027-9257)
- Yuhan Chen (ORCID: https://orcid.org/0000-0001-9796-0291)
- Yin Zhu (ORCID: https://orcid.org/0000-0002-7561-2306)
- Ziling Zhu (ORCID: https://orcid.org/0000-0002-6601-1648)
- Jing Tan (ORCID: https://orcid.org/0009-0001-3443-4419)
- Jingyao Xu
- Jiangjiang Zheng
- Hong Deng (ORCID: https://orcid.org/0000-0002-1154-296X)
- Xiujin Shen
Institutions
- Chinese Academy of Sciences (CN)
- Zhejiang Cancer Hospital (CN)
- Integrated Chinese Medicine (China) (HK)
- Ningbo No. 2 Hospital (CN)
- Zhejiang Center for Disease Control and Prevention (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Hunan Provincial People's Hospital (CN)
- Colorado Kidney Care (US)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Hangzhou Cancer Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Cancer Biology & Therapy
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1080/15384047.2025.2589645
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00