Evaluation of Stress-Dose Steroid Weaning Strategies in Patients Following Septic Shock

Rapid corticosteroid tapering in septic shock patients was associated with a reduced incidence of vasopressor reinitiation, shorter ICU and hospital stay, and a lower incidence of hypernatremia. These findings enhance our understanding of tapering strategies and suggest that rapid tapering (<72 hours) in septic shock may improve patient outcomes, informing future clinical guidelines.

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Publication Details

Journal
Annals of Pharmacotherapy
Published
2025-12-07
DOI
https://doi.org/10.1177/10600280251385523
Primary Topic
Adrenal Hormones and Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Evaluation of Stress-Dose Steroid Weaning Strategies in Patients Following Septic Shock

John Alex Toler, Evan Westlake, Jade M. Denninger, Steven Skovran
Annals of Pharmacotherapy
Adrenal Hormones and Disorders
article

Evaluation of Stress-Dose Steroid Weaning Strategies in Patients Following Septic Shock

John Alex Toler, Evan Westlake, Jade M. Denninger, Steven Skovran
article en

Abstract

Rapid corticosteroid tapering in septic shock patients was associated with a reduced incidence of vasopressor reinitiation, shorter ICU and hospital stay, and a lower incidence of hypernatremia. These findings enhance our understanding of tapering strategies and suggest that rapid tapering (<72 hours) in septic shock may improve patient outcomes, informing future clinical guidelines.

Annals of Pharmacotherapy
Rex Hospital (US)
Openalex Percentile: Top 49%
Adrenal Hormones and Disorders
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