Preventing Neurons and Glial Cells Destruction in Substantia Nigra Pars Compacta and Striatum Using St. John's Wort and Stem Cells on Parkinson's Model
The study found that both H. perforatum extract and BMSCs can help preserve dopaminergic neurons and glial cells during which combination therapy demonstrates synergy as an indicator. St. John's is a natural preserver and appears to function as a neuroprotective agent and facilitate the navigation and integration of stem cells; consequently, it keeps surviving both neurons and glial cells against pathogens and destructive environmental factors and has a potential to help us and Parkinson's patients.
Authors
- Manouchehr Safari (ORCID: https://orcid.org/0000-0001-6975-7747)
- Majid Mirmohammadkhani (ORCID: https://orcid.org/0000-0001-6251-7484)
- Ali Khaleghian (ORCID: https://orcid.org/0000-0001-8520-6654)
- Laya Ghahari (ORCID: https://orcid.org/0000-0003-3946-8965)
- Abbas Ali Vafaei (ORCID: https://orcid.org/0000-0003-1178-3787)
- Hamed Farzadmanesh (ORCID: https://orcid.org/0000-0002-3061-990X)
- Hamidreza Sameni
- Ali Ghanbari (ORCID: https://orcid.org/0000-0002-7568-3681)
- Afsaneh Shokri
Institutions
- Aja University of Medical Sciences (IR)
- Global College (CY)
- Muscat College (OM)
- Semnan University of Medical Sciences (IR)
- Semnan University (IR)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/brb3.71124
- Primary Topic
- Plant and Biological Electrophysiology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Semnan University of Medical Sciences and Health Services