Narcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review
The existing therapeutic approach to narcolepsy is palliative, not restorative, leaving a significant unmet need for interventions that can alter the disease's natural history. The future of narcolepsy management depends on translating novel pathophysiological insights into disease-modifying therapies. Achieving this requires a concerted effort to accelerate diagnosis, validate new clinical endpoints, and prioritize the development of interventions capable of restoring neurological function. Such an approach holds the potential to move beyond symptom suppression and fundamentally improve the lives of individuals with narcolepsy.
Authors
- Fazeela Bibi
- James D. Hanna
- M Núñez
- Uzma Alam (ORCID: https://orcid.org/0009-0001-0456-022X)
- Natasha Hastings (ORCID: https://orcid.org/0009-0005-7769-2716)
- Bilal Aslam (ORCID: https://orcid.org/0000-0001-7308-5285)
- Hamayun Imran (ORCID: https://orcid.org/0000-0002-2261-4455)
- Sujeet Shadmani
- Said Hamid Sadat (ORCID: https://orcid.org/0009-0006-7885-6214)
- Vohra Maham Hassan
- Khalil El Abdi (ORCID: https://orcid.org/0009-0009-6138-6684)
- Hoor‐e‐Ainaa
- Muhammad Tahla Rehman Sherani
Institutions
- Mohammed V University (MA)
- St. George's University (GD)
- Ayub Medical College (PK)
- University of Lahore (PK)
- Khyber Medical College (PK)
- Kabul University (AF)
- University of Wah (PK)
- Khyber Medical University (PK)
- Kabul University of Medical Sciences Abu Ali Ibn Sina (AF)
- Shaheed Mohtarma Benazir Bhutto Medical University (PK)
- Jinnah Medical & Dental College (PK)
- Universidad Iberoamericana (DO)
- Army Medical College (PK)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/brb3.71116
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00