Efficacy of pharmacotherapies on pediatric patients with metabolic dysfunction-associated steatotic liver disease: a systematic review and network meta-analysis
Our NMA suggests pharmacotherapy holds promise for pediatric MASLD, with vitamin D and vitamin E presenting the most consistent benefits across histologic and laboratory outcomes. Future well-designed RCTs integrating standardized MASLD diagnosis and lifestyle interventions are warranted.
Authors
- Ahmed Heiba (ORCID: https://orcid.org/0000-0002-5200-5458)
- Heba Aboeldahab (ORCID: https://orcid.org/0000-0001-9837-1763)
- Sameer Yaser (ORCID: https://orcid.org/0009-0004-6874-3393)
- Mohamed Nasser (ORCID: https://orcid.org/0000-0002-7164-2479)
- Zeyad Bady (ORCID: https://orcid.org/0000-0002-1327-1892)
- M.K. Darwish
- Hazem E. Mohammed
- Mohamed E. Haseeb
- Mohamed Mabrouk Ghonaim
- Hatem Yaser
Institutions
- Menoufia University (EG)
- Minia University (EG)
- Assiut University (EG)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12876-025-04393-x
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Development Fund