Bifidobacterium enhances the antitumor efficacy of carboplatin in glioblastoma cells: targeting apoptotic and cell cycle regulatory pathways via Caspase, AKT/PTEN, and P53/P21 signaling
B. reuteri Ab.338 SH enhances Carboplatin efficacy in GBM cells while lowering its required dose and potential toxicity. This probiotic may serve as a promising adjuvant in GBM therapy, warranting further in vivo validation.
Authors
- Mohammad Bagher Nazari (ORCID: https://orcid.org/0000-0001-6015-3525)
- Asghar Parsaei (ORCID: https://orcid.org/0000-0001-7852-8129)
- Ahmad Gholami (ORCID: https://orcid.org/0000-0003-1851-159X)
- Abbas Asoudeh-Fard (ORCID: https://orcid.org/0000-0002-6552-5268)
- Mohammad Abbasi (ORCID: https://orcid.org/0009-0006-3679-6217)
- Mohadeseh Asoudeh-Fard
- Moein Yeylagh-Beygi
Institutions
- Tabriz University of Medical Sciences (IR)
- Shiraz University of Medical Sciences (IR)
- Biotechnology Research Center (IR)
- Université Sorbonne Paris Nord (FR)
- Islamic Azad University, Zahedan Branch (IR)
- Université Paris 1 Panthéon-Sorbonne (FR)
- Islamic Azad University of Shiraz (IR)
- Semnan University (IR)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12935-025-04099-w
- Citations
- 2
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.47