Single-cell transcriptomics reveals systemic immune dysregulation in non-segmental vitiligo
This study provides the single-cell atlas of PBMCs in GP-NSV, uncovering profound transcriptional and compositional alterations across multiple immune cell subsets in active vitiligo. These findings offer novel insights into systemic immune dysregulation in GP-NSV and pave the way for novel targeted therapeutic strategies.
Authors
- Qinhui Li (ORCID: https://orcid.org/0009-0009-6877-6415)
- Yujie Mao
- Jialing Xiao (ORCID: https://orcid.org/0000-0002-4081-5525)
- Liao‐Kuo Gong (ORCID: https://orcid.org/0000-0003-1167-5399)
- Xiaojuan Guo (ORCID: https://orcid.org/0000-0002-1960-183X)
- Han Liang (ORCID: https://orcid.org/0000-0001-7633-286X)
- Kai Dong (ORCID: https://orcid.org/0000-0001-6314-1546)
- Ting Wang (ORCID: https://orcid.org/0000-0002-6569-4395)
- Liang Wang (ORCID: https://orcid.org/0000-0002-5247-6727)
- Mingze Li (ORCID: https://orcid.org/0000-0001-8271-5576)
- Jianing Yang (ORCID: https://orcid.org/0009-0004-2565-8260)
- Yifan Hu (ORCID: https://orcid.org/0000-0003-1872-3453)
- Yixuan Jiang (ORCID: https://orcid.org/0000-0001-5767-0206)
- Bo Gong (ORCID: https://orcid.org/0000-0001-8013-4196)
- Weijia Wu (ORCID: https://orcid.org/0000-0003-2293-1335)
- Yufang Wu
- Chengzi Gan
- Xiaoxin Guo
- Huan Li (ORCID: https://orcid.org/0000-0001-6624-9755)
Institutions
- Guiyang Medical University (CN)
- University of Electronic Science and Technology of China (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1698566
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00