Automated radiosynthesis and clinical experience of [18F]SMBT-1 PET imaging for in vivo evaluation of reactive astrocyte in Parkinson's disease: a pilot study
The automated radiosynthesis of [<sup>18</sup>F]SMBT-1 are suitable for routine production without any immediate complication reported after administration. Moderate PD shows decreased astrocyte function as they lose neuroprotective astrocytes while severe PD shows increased astrocyte function as increased neurotoxic astrocytes.
Authors
- Attapon Jantarato (ORCID: https://orcid.org/0000-0002-5801-9391)
- P. Kongsakorn
- Chetsadaporn Promteangtrong (ORCID: https://orcid.org/0000-0002-8367-9543)
- Ryuichi Harada (ORCID: https://orcid.org/0000-0001-8538-8814)
- Arthita Choolam
- Pradith Lerdsirisuk
- Nirawan Fonghoi
- Peerapon Kiatkittikul (ORCID: https://orcid.org/0000-0001-7076-3829)
- Shozo Furumoto (ORCID: https://orcid.org/0000-0002-9296-3079)
- Nobuyuki Okamura (ORCID: https://orcid.org/0000-0002-5991-7812)
- Saiphet Vanprom
- Laksika Bhuthathorn
- Wisakha Chintawan
- Thanapon Sringam
Institutions
- Tohoku University (JP)
- Chulabhorn Hospital (TH)
- Tohoku Medical and Pharmaceutical University (JP)
Publication Details
- Journal
- Frontiers in Nuclear Medicine
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fnume.2025.1718255
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chulabhorn Royal Academy