A multi-omic machine learning approach deconstructs the role of amino acid metabolism in the immune microenvironment and prognosis of colon adenocarcinoma
Histidine metabolism is a critical regulator of the COAD immune microenvironment. Our prognostic model, the HRM, provides a clinically relevant tool for risk stratification, while its key mediator, TRIP6, represents a novel therapeutic target linking tumor metabolism to immune evasion.
Authors
- Chenfei Jiang (ORCID: https://orcid.org/0000-0001-9561-7350)
- Hua Zhong (ORCID: https://orcid.org/0000-0002-4403-6123)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-9357-1205)
- Wenbing Zhang (ORCID: https://orcid.org/0000-0001-8553-6565)
- Nuo Chen (ORCID: https://orcid.org/0009-0000-2895-746X)
- A. Liu
- Zirui He
- J. Jin
Institutions
- Ruijin Hospital (CN)
- Anqing City Hospital (CN)
- First People's Hospital of Nanning (CN)
- Nanjing Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1719555
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00