Multi-omics spatial characteristics of CD8+TRM cells in hepatocellular carcinoma and immunotherapy response prediction
Immunotherapy can modify the spatial characteristics of CD8<sup>+</sup> TRM cells via regulating their crosstalk with other immune cells, and the spatial distribution of CD8<sup>+</sup> TRM cells in the HCC tumor microenvironment (TME) correlates with immune checkpoint blockade (ICB) therapeutic efficacy. Clarifying the mechanisms of action of immunotherapeutic drugs and developing a non-invasive radiomics model to predict CD8⁺ TRM cell dynamics will facilitate the clinical management of HCC.
Authors
- Bingbing Qiao (ORCID: https://orcid.org/0000-0002-3835-5881)
- Jinzhen Cai (ORCID: https://orcid.org/0000-0001-5414-1050)
- Shipeng Li (ORCID: https://orcid.org/0000-0001-8615-2440)
- Jiahui Ma
- Liancai Wang
- Deyu Li (ORCID: https://orcid.org/0000-0002-6615-8316)
- Xinqiang Li (ORCID: https://orcid.org/0000-0002-4193-4227)
- Hua Zhou (ORCID: https://orcid.org/0000-0002-0725-624X)
Institutions
- Qingdao University (CN)
- Fujian Medical University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Henan Provincial People's Hospital (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Union Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1710741
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00