The local cellular response to Human Papillomavirus focuses on basal layer restoration as visualized in situ by specific cellular neighborhoods near infected cells
In conclusion, spatial analysis reveals that HPV16 infection orchestrates a coordinated tissue response, driving basal layer restoration while locally suppressing immune activation to prevent pathological damage.
Authors
- Ziena Abdulrahman (ORCID: https://orcid.org/0000-0001-9079-0293)
- Roderick C. Slieker (ORCID: https://orcid.org/0000-0003-0961-9152)
- Saskia J. Santegoets (ORCID: https://orcid.org/0000-0002-2874-4402)
- Mariëtte I.E. van Poelgeest (ORCID: https://orcid.org/0000-0001-5432-5001)
- Marij J.P. Welters (ORCID: https://orcid.org/0000-0002-9809-8266)
- Sjoerd H. van der Burg
Institutions
- Leiden University Medical Center (NL)
- Oncode Institute (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1728629
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00