Pterostilbene mitigates the senescence of human dermal fibroblast cells by enhancing mitochondrial quality
Our findings demonstrate that PT delays dermal senescence by enhancing mitochondrial quality via enhancing mitophagy. These results highlight PT as a promising anti-aging agent capable of countering both intrinsic and extrinsic aging in the dermis.
Authors
- Guizhi Li
- Ning Wang (ORCID: https://orcid.org/0000-0003-4647-5880)
- Chang Liu (ORCID: https://orcid.org/0000-0002-7318-1004)
- Jingxi Wei (ORCID: https://orcid.org/0000-0001-6734-7410)
- Xu Dong Zhang (ORCID: https://orcid.org/0000-0001-9457-8003)
- Zhe Feng (ORCID: https://orcid.org/0000-0002-7851-8999)
- Zhengwei Lue
- Yue Li (ORCID: https://orcid.org/0000-0002-1271-0283)
- Minjie Zhang (ORCID: https://orcid.org/0000-0001-8561-0729)
- Huang Hu (ORCID: https://orcid.org/0000-0003-1296-1645)
- Xinyu Zhou (ORCID: https://orcid.org/0000-0002-9647-1100)
- Qi Bao
- Jing Wang (ORCID: https://orcid.org/0000-0001-7431-8925)
Institutions
- Cosmetics Europe (BE)
- Jinhua Academy of Agricultural Sciences (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fphar.2025.1732154
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province