Moxibustion combined with chemotherapy inhibits gastric cancer growth by modulating the immunosuppressive microenvironment involving the Treg/IL-10/TGF-β1 axis
This study is the first to demonstrate that moxibustion synergizes with chemotherapy to inhibit gastric cancer growth through bidirectional remodeling of the immune microenvironment, simultaneously attenuating immunosuppression and boosting immune attack. Our findings provide a novel mechanistic insight into the integrated "Guben Peiyuan" and Western medicine strategy for GC.
Authors
- Wanhui Dong (ORCID: https://orcid.org/0000-0002-6470-4643)
- Yanqi Ding
- Yue Leng (ORCID: https://orcid.org/0000-0001-5826-4031)
- Xiaoming Zhou (ORCID: https://orcid.org/0000-0001-8866-7245)
- Li Ma (ORCID: https://orcid.org/0000-0003-0894-7867)
- Yong Wu (ORCID: https://orcid.org/0000-0001-9840-940X)
- Yong-Lei Zeng
- Wanrong Hao
- Mengying Mao (ORCID: https://orcid.org/0000-0002-5351-844X)
- Heng Xu (ORCID: https://orcid.org/0000-0001-8457-7613)
Institutions
- Anhui Medical University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Lu'an First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fphar.2025.1688182
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui University
- Anhui University of Chinese Medicine