Concentration monitoring and dose optimization for infliximab in Crohn’s disease patients: a machine learning-based covariate ensemble model
We developed and validated an interpretable ensemble model that can dynamically monitor drug concentrations and optimize personalized dosing of IFX therapy in CD patients, demonstrating the potential of an ML-based approach to enhance treatment efficacy and safety.
Authors
- Zhou-Jie Liu
- Sining Zhang (ORCID: https://orcid.org/0000-0003-3748-9121)
- Jianwen Xu (ORCID: https://orcid.org/0000-0002-8095-591X)
- Rongfang Lin (ORCID: https://orcid.org/0000-0002-4810-0428)
- Si Chen (ORCID: https://orcid.org/0000-0002-0305-8641)
- Shaojun Jiang (ORCID: https://orcid.org/0000-0002-6722-0978)
- Jing Liu (ORCID: https://orcid.org/0000-0002-6745-3050)
- Shaopeng Zhou (ORCID: https://orcid.org/0000-0001-7226-090X)
- Yuewen Chen (ORCID: https://orcid.org/0000-0001-5388-6616)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1715241
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fujian Medical University