Changes in attitudes towards prenatal diagnosis for haemoglobinopathies: a 40-year retrospective observational study in Northern Italy
The 40-year analysis of prenatal diagnosis for haemoglobinopathies in Turin shows evolving trends influenced by immigration patterns, improved medical treatments and cultural factors, leading to increased acceptance of affected pregnancies in recent years, particularly after 2015, due to better disease management and comprehensive healthcare support. This comprehensive analysis of our centre's experience provides valuable insights that can serve as a model for similar institutions worldwide in supporting couples through carrier screening and PND processes.
Authors
- Andrea Sciarrone (ORCID: https://orcid.org/0000-0001-7023-2710)
- Antonio Piga (ORCID: https://orcid.org/0000-0002-2197-1899)
- Giorgia Mandrile (ORCID: https://orcid.org/0000-0003-0849-2225)
- Antonella Roetto (ORCID: https://orcid.org/0000-0003-1188-7375)
- Luca Sbaiz
- Cristina Curcio (ORCID: https://orcid.org/0009-0000-2352-0357)
- Daniela Giachino (ORCID: https://orcid.org/0000-0002-3186-6726)
- Veronica Sciannameo (ORCID: https://orcid.org/0000-0002-0499-0131)
- Vincenzo Voi (ORCID: https://orcid.org/0000-0001-7249-2735)
- Milena Agata Irrera
- Marco Barberis
- Noemi Giordano
Institutions
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale Sant'Anna (IT)
- Ospedale San Luigi Gonzaga (IT)
- University of Turin (IT)
Publication Details
- Journal
- BMJ Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/bmjopen-2025-106796
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft