Developing a core outcome set for clinical trials of traditional Chinese medicine for rheumatoid arthritis
This study developed the first COS-TCM-RA, comprising 11 indicators across five domains: overall disease evaluation, physical and chemical indicators, quality of life, TCM syndromes, and adverse events. By integrating internationally recognized RA assessment tools with patient-reported outcomes and TCM-specific measures, the COS-TCM-RA provides a standardized, multi-dimensional framework to enhance trial quality, improve comparability, and support the integration and internationalization of TCM in evidence-based medicine.
Authors
- Xiaopo Tang (ORCID: https://orcid.org/0000-0002-0569-4502)
- Quan Jiang (ORCID: https://orcid.org/0000-0002-3031-7848)
- Jingdong Yang (ORCID: https://orcid.org/0000-0003-1296-8230)
- Congmin Xia
- Mengge Song (ORCID: https://orcid.org/0000-0001-7353-9099)
- Junjie Zhang (ORCID: https://orcid.org/0000-0002-7145-8233)
- Bingbing Yu (ORCID: https://orcid.org/0000-0002-8041-4128)
- Xinming Zhao (ORCID: https://orcid.org/0000-0002-3976-111X)
- Man Seok Han
Institutions
- University of Shanghai for Science and Technology (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fmed.2025.1690963
- Citations
- 1
- Primary Topic
- Delphi Technique in Research
- Type
- article
- Field-Weighted Citation Impact
- 4.20
Funders
- China Academy of Chinese Medical Sciences