Haematologic responses to primaquine used for radical cure of Plasmodium vivax in public health facilities in Ethiopia: a prospective observational study
In this study, conducted in a population with a low prevalence of G6PD deficiency, a 14-day regimen of low-dose primaquine was well tolerated and resulted in few mild adverse events only. These findings support the current national policy for low-dose primaquine in Ethiopia without prior G6PD testing, if systems for monitoring adverse events are in place.
Authors
- Samuel Girma (ORCID: https://orcid.org/0000-0002-0630-4553)
- Ric N. Price (ORCID: https://orcid.org/0000-0003-2000-2874)
- Ellora Karmarkar (ORCID: https://orcid.org/0000-0002-6657-0052)
- Semira Abdelmenan (ORCID: https://orcid.org/0000-0003-2753-8364)
- Ayele Zewde
- Tigest Shifraw (ORCID: https://orcid.org/0000-0002-2387-9869)
- Peter Mumba (ORCID: https://orcid.org/0000-0002-4198-5542)
- Matthew Murphy (ORCID: https://orcid.org/0000-0003-0427-2460)
- Yemane Berhane (ORCID: https://orcid.org/0000-0002-2527-1339)
- Sheleme Chibsa
- Kebede Etana
- Jimee Hwang (ORCID: https://orcid.org/0000-0002-9890-2664)
- Hiwot Teka
- Joseph Keating
- Hussein Mohammed (ORCID: https://orcid.org/0009-0001-8448-7690)
- Alemayehu Worku
- Adugna Abera (ORCID: https://orcid.org/0000-0001-6572-8113)
Institutions
- Tulane University (US)
- Centers for Disease Control and Prevention (US)
- Addis Continental Institute of Public Health (ET)
- Federal Ministry of Health (NG)
- Mahidol University (TH)
- Government of Ethiopia (ET)
- Charles Darwin University (AU)
- University of Oxford (GB)
- Menzies School of Health Research (AU)
- U.S. President's Malaria Initiative (US)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Epidemic Intelligence Service (US)
- International Trachoma Initiative (ET)
- Addis Ababa University (ET)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12936-025-05709-8
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00