Plastic cannulas mitigate arteriovenous fistula stenosis by suppressing the CFB-mediated inflammatory cascade
The alternative complement pathway is significantly activated during initial AVF cannulation, with excessive CFB production contributing substantially to AVF failure. The use of plastic cannulas may improve long-term AVF patency by mitigating endothelial dysfunction and inhibiting inflammatory cell infiltration through suppression of CFB generation.
Authors
- Ka Qi
- Dongjuan Zhang
- Deyang Kong (ORCID: https://orcid.org/0000-0002-5044-2531)
- Yang Yang (ORCID: https://orcid.org/0000-0003-4347-0064)
- Ma Lu (ORCID: https://orcid.org/0000-0001-8736-279X)
- Mingming Zhao
- Z. W. Ou (ORCID: https://orcid.org/0000-0002-3632-474X)
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- People's Liberation Army 401 Hospital (CN)
- Chengde Medical University (CN)
- Qinhuangdao Glass Industry Research and Design Institute (China) (CN)
- Shenzhen Bao'an District People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1715417
- Primary Topic
- Central Venous Catheters and Hemodialysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00