The role of eplet matching in solid organ transplantation
Eplet matching demonstrates significant potential to improve risk stratification and long-term graft outcomes across SOT. However, clinical translation is limited by inconsistent methods, equity concerns, and the absence of standardized epMM thresholds. Prospective studies, harmonized molecular typing, and integration with allocation frameworks are needed to establish the clinical utility and policy implications of molecular-level HLA matching.
Authors
- Viola A. Stögner
- Bohdan Pomahač (ORCID: https://orcid.org/0000-0003-3703-8240)
- Siba Haykal (ORCID: https://orcid.org/0000-0002-4247-2810)
- Lauren Harkins
- Richard N. Formica (ORCID: https://orcid.org/0000-0001-6452-3976)
- Dean M. Pucciarelli (ORCID: https://orcid.org/0000-0003-2227-6983)
- Adam Littleton
Institutions
- Rutgers, The State University of New Jersey (US)
- Johnson University (US)
- Yale University (US)
- Medizinische Hochschule Hannover (DE)
Publication Details
- Journal
- Frontiers in Transplantation
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/frtra.2025.1710058
- Citations
- 1
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.99