Enhancing functional antibody responses against HIV envelope V1V2 through vaccine formulations

Data from this study provide new insights into the utility of novel formulations for V1V2-scaffold immunogens as a strategy for optimizing the induction of functional V1V2-specific antibodies to improve HIV vaccine efficacy.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-12-08
DOI
https://doi.org/10.3389/fimmu.2025.1722596
Primary Topic
HIV Research and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Enhancing functional antibody responses against HIV envelope V1V2 through vaccine formulations

Michael Schotsaert, Chitra Upadhyay, Priyanka Gadam Rao, Matthew J. Wiest et al.
Frontiers in Immunology
HIV Research and Treatment
article

Enhancing functional antibody responses against HIV envelope V1V2 through vaccine formulations

Michael Schotsaert, Chitra Upadhyay, Priyanka Gadam Rao, Matthew J. Wiest, Jéromine Klingler, Pamela T. Wong, Seok‐Chan Park, Bruno G. De Geest, Clauvis Kunkeng Yengo, Ying K. Tam, Gabriel Laghlali, Xiang‐Peng Kong, Christina C. Luo, Norbert Pardi, Catarina E. Hioe, Xiaomei Liu, Hiromi Muramatsu, Xunqing Jiang
article en

Abstract

Data from this study provide new insights into the utility of novel formulations for V1V2-scaffold immunogens as a strategy for optimizing the induction of functional V1V2-specific antibodies to improve HIV vaccine efficacy.

Frontiers in ImmunologyVol. 16
HOGENT University of Applied Sciences and Arts (BE), University of Michigan (US), Ghent University Hospital (BE), Ghent University (BE), James J. Peters VA Medical Center (US), Acuitas Therapeutics (Canada) (CA), New York University (US), University of Pennsylvania (US), Icahn School of Medicine at Mount Sinai (US)
U.S. Department of Veterans Affairs, National Institutes of Health, National Institute of Allergy and Infectious Diseases
Openalex Percentile: Top 59%
HIV Research and Treatment
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