Enhancing functional antibody responses against HIV envelope V1V2 through vaccine formulations
Data from this study provide new insights into the utility of novel formulations for V1V2-scaffold immunogens as a strategy for optimizing the induction of functional V1V2-specific antibodies to improve HIV vaccine efficacy.
Authors
- Michael Schotsaert (ORCID: https://orcid.org/0000-0003-3156-3132)
- Chitra Upadhyay (ORCID: https://orcid.org/0000-0002-4524-1532)
- Priyanka Gadam Rao (ORCID: https://orcid.org/0009-0004-6219-5429)
- Matthew J. Wiest (ORCID: https://orcid.org/0009-0006-7360-638X)
- Jéromine Klingler (ORCID: https://orcid.org/0000-0002-2313-9932)
- Pamela T. Wong (ORCID: https://orcid.org/0000-0002-4387-4723)
- Seok‐Chan Park (ORCID: https://orcid.org/0000-0003-2489-2202)
- Bruno G. De Geest (ORCID: https://orcid.org/0000-0001-9826-6170)
- Clauvis Kunkeng Yengo (ORCID: https://orcid.org/0000-0001-7579-9708)
- Ying K. Tam (ORCID: https://orcid.org/0000-0002-4083-5251)
- Gabriel Laghlali (ORCID: https://orcid.org/0009-0009-7928-984X)
- Xiang‐Peng Kong (ORCID: https://orcid.org/0000-0001-5773-2681)
- Christina C. Luo (ORCID: https://orcid.org/0000-0001-9872-7432)
- Norbert Pardi (ORCID: https://orcid.org/0000-0003-1008-6242)
- Catarina E. Hioe (ORCID: https://orcid.org/0000-0002-9245-9788)
- Xiaomei Liu (ORCID: https://orcid.org/0000-0001-6134-0197)
- Hiromi Muramatsu
- Xunqing Jiang
Institutions
- HOGENT University of Applied Sciences and Arts (BE)
- University of Michigan (US)
- Ghent University Hospital (BE)
- Ghent University (BE)
- James J. Peters VA Medical Center (US)
- Acuitas Therapeutics (Canada) (CA)
- New York University (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1722596
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases