Comprehensive analysis of palmitoylation-related proteins for prognostic risk evaluation and tumor immune microenvironment assessment in glioma
A significant correlation exists between palmitoylation and tumor microenvironment in glioma. The PRRS emerges as a dependable prognostic biomarker, offering therapeutic advantages in the context of chemotherapy and immunotherapy, and potentially aiding in clinical decision-making for glioma patients. The identified compounds, AT-7519, BIX02189, and THZ-2-101-1, may potentially exert inhibitory effects on the malignant progression of glioma by targeting palmitoylation-related proteins.
Authors
- Jie Zhou (ORCID: https://orcid.org/0000-0003-0755-4818)
- Qingsong Yin (ORCID: https://orcid.org/0000-0002-1703-1175)
- Chang Liu (ORCID: https://orcid.org/0009-0007-3808-1466)
- Rui Lai (ORCID: https://orcid.org/0000-0002-6486-7151)
- Ming Wang (ORCID: https://orcid.org/0000-0002-0384-1767)
- Tao Wang (ORCID: https://orcid.org/0000-0002-5728-6463)
- Ligang Chen (ORCID: https://orcid.org/0000-0003-0516-4496)
- Liping Lin (ORCID: https://orcid.org/0009-0003-8741-263X)
- Yiran Yin
- Jihao Xue (ORCID: https://orcid.org/0009-0001-8263-0772)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- Dazhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1599769
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00