Exhaustion of NK cells and interferon activation in anti-MDA5+ dermatomyositis are associated and determine the development of ILD
Excessive IFN activation drives NK cell apoptosis in anti-MDA5<sup>+</sup> DM-ILD, contributing to NK cell depletion and ILD development. IFN-related biomarkers may serve as valuable indicators for assessing ILD severity in these patients.
Authors
- Ninghui Yan
- Chenyi Shao
- Yanqing Guo (ORCID: https://orcid.org/0000-0001-9123-140X)
- Nana Xia
- Xueliang Zhang (ORCID: https://orcid.org/0000-0001-6188-0257)
- Yan Zhen
- Qiang Guo (ORCID: https://orcid.org/0000-0002-7325-7961)
- Lixing Tan (ORCID: https://orcid.org/0000-0002-0323-8802)
- Mengmeng Zhou
Institutions
- Renji Hospital (CN)
- Jiading District Central Hospital (CN)
- Vanke (China) (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1697803
- Citations
- 1
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 1.35