Gut mucosa-associated microbiota signatures in healthy individuals and patients at different stages of liver disease: a pilot study
Our pilot study suggests that MAM alterations do not directly mirror liver disease progression but show distinct patterns associated with different stages. These associations, more evident in advanced disease, involve bacterial taxa linked to gut integrity, inflammation, and carcinogenesis. This exploratory work lays the groundwork for future studies to validate these findings and investigate their relevance to microbiome-based diagnostics and therapies in HCC.
Authors
- Marco Sanduzzi Zamparelli
- Graziano Pesole (ORCID: https://orcid.org/0000-0003-3663-0859)
- Alba Rocco (ORCID: https://orcid.org/0000-0003-0959-1807)
- Federica Di Maggio (ORCID: https://orcid.org/0009-0008-5917-1492)
- Costantino Sgamato (ORCID: https://orcid.org/0000-0001-7188-5174)
- Ilaria Granata (ORCID: https://orcid.org/0000-0002-3450-4667)
- Debora Compare (ORCID: https://orcid.org/0000-0002-6092-4921)
- Pietro Coccoli
- Bruno Fosso (ORCID: https://orcid.org/0000-0003-2324-086X)
- Giorgio Casaburi (ORCID: https://orcid.org/0000-0002-5980-8704)
- Valeria D’Argenio (ORCID: https://orcid.org/0000-0001-9273-3698)
- Gerardo Nardone (ORCID: https://orcid.org/0000-0001-8344-6523)
- Marcella Nunziato (ORCID: https://orcid.org/0000-0003-1999-4992)
- Domenica Lovero (ORCID: https://orcid.org/0000-0002-7883-8896)
- Francesco Salvatore (ORCID: https://orcid.org/0000-0003-0212-1271)
Institutions
- Institute for High Performance Computing and Networking (IT)
- Federico II University Hospital (IT)
- CEINGE Biotecnologie Avanzate Franco Salvatore (Italy) (IT)
- Institute of Bioinformatics (IN)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Gut Pathogens
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s13099-025-00767-4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00