<b> Antibacterial and cytotoxic effects of chlorhexidine combined with sodium DNA on oral microorganisms: an <i>in vitro</i> study using </b> <i> <b>Dictyostelium discoideum</b> </i>
This study integrates antimicrobial, antibiofilm, cellular, and metabolomic analyses to assess CHX with sodium DNA. Sodium DNA reduces CHX-induced cytotoxicity and metabolic stress while maintaining antimicrobial activity, offering insights for optimizing oral hygiene formulations through combined microbial and host-cell evaluation.
Authors
- Gaia Vertillo Aluisio (ORCID: https://orcid.org/0000-0003-4534-4176)
- Alessandra Romano (ORCID: https://orcid.org/0000-0002-6333-4433)
- Maria Lina Mezzatesta (ORCID: https://orcid.org/0000-0003-0853-9564)
- Simone Rocco (ORCID: https://orcid.org/0000-0001-8805-959X)
- Cristina Panuzzo (ORCID: https://orcid.org/0000-0002-2814-6453)
- Barbara Pergolizzi (ORCID: https://orcid.org/0000-0003-4686-0068)
- Maria Santagati (ORCID: https://orcid.org/0000-0003-1491-4973)
- Gaetano Isola (ORCID: https://orcid.org/0000-0003-4267-6992)
- Valentina Schiavo
- Adriana Antonina Tempesta
Institutions
- Zimmer Biomet (Netherlands) (NL)
- British Society of Periodontology (GB)
- University of Catania (IT)
- Policlinico Universitario di Catania (IT)
- University of Turin (IT)
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1080/20002297.2025.2595797
- Citations
- 7
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 10.26