Hydroxysafflor Yellow A Mitigates Sepsis-Induced Pulmonary and Intestinal Injury by Inhibiting TP53 Mediated Ferroptosis
This study clarified the role of TP53-mediated ferroptosis in sepsis-induced intestinal barrier dysfunction and discovered that HSYA could improve sepsis as an inhibitor of TP53, offering new strategies for the treatment of sepsis.
Authors
- Shifeng Shao (ORCID: https://orcid.org/0000-0003-0780-1137)
- Qing Chen (ORCID: https://orcid.org/0000-0003-4108-7977)
- Jingyi Fei
- Yingjie Wang (ORCID: https://orcid.org/0000-0001-8769-1948)
- Chencheng Xu
- Yaoli Wang (ORCID: https://orcid.org/0000-0002-6815-7616)
- Zhengbin Wu (ORCID: https://orcid.org/0000-0001-9397-9104)
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- Chinese People 's Liberation Army No.455 Hospital (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/idr.s528964
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52