Iron status mediates the causal effects of high-altitude adaptation signals in the HIF–PHD axis on pulmonary vascular and right-heart outcomes
EGLN1-driven erythropoietic upregulation increases PE risk and adversely affects pulmonary artery structure, whereas higher EPAS1 expression reduces PE risk. These genetic findings support targeted modulation of HIF-2α and iron metabolism.
Authors
- Youqian Zhang (ORCID: https://orcid.org/0009-0003-9372-5923)
- Jiejun Zhou (ORCID: https://orcid.org/0000-0001-8503-3810)
- Chang Liu (ORCID: https://orcid.org/0000-0002-2788-0285)
- Mingwei Chen
- Wenrui Li (ORCID: https://orcid.org/0000-0002-9353-6722)
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Clinical and Experimental Hypertension
- Published
- 2025-12-07
- DOI
- https://doi.org/10.1080/10641963.2025.2595152
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 0.00