Comparative analysis of molecular targeted radiosensitizers in 2D and 3D cancer cell line models
Integrating multiple culture models enhances the detection of cell line - and drug-specific radiosensitization. Although 2D and 3D cultures produced largely similar results, and 2D assays provide a practical alternative when 3D methods are not feasible, the 3D cultures reveal additional ECM-dependent responses. These results emphasize the utility of physiologically relevant platforms for robust screening and prioritization of candidate radiosensitizers.
Authors
- Mechthild Krause (ORCID: https://orcid.org/0000-0003-1776-9556)
- Manuel Pfeifer
- Nathalie Borgeaud
- Antje Dietrich (ORCID: https://orcid.org/0000-0002-9783-1104)
- Henning Willers (ORCID: https://orcid.org/0000-0002-3938-5732)
- Michael Ramírez Parra (ORCID: https://orcid.org/0000-0002-8459-2159)
Institutions
- Harvard University (US)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Heidelberg (DE)
- Massachusetts General Hospital (US)
- National Center for Tumor Diseases (DE)
- University Hospital Carl Gustav Carus (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Acta Oncologica
- Published
- 2025-12-07
- DOI
- https://doi.org/10.2340/1651-226x.2025.43916
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health